Monday, October 16, 2017
12:00 pm-1:00 pm

CVS Research Talk: Ed Lalor
  Event title:CVS Research Talk: Early visual processing deficits in schizophrenia: investigating the two-stream hypothesis.
  Speaker:Ed Lalor
  Affiliation:U. Rochester, BME
  Location:269 Meliora Hall, Kresge Rm
  Abstract:Deficits in sensory processing have been widely reported in patients with schizophrenia using both behavioral and neurophysiological measures. These sensory processing deficits are now being used as endophenotypes to identify genes involved in familial transmission of schizophrenia and to monitor therapeutic drug response for both treatment and prevention. Furthermore, because low-level sensory deficits can negatively impact higher order cognitive function, an understanding of the basis for these deficits offers potential for improving cognition in this terribly debilitating disease. One active area of research on this topic is the use of EEG to study visual processing deficits in patients with schizophrenia. A number of these studies point to a high degree of specificity in the dysfunction underlying these deficits. This has led researchers to implicate certain neurotransmitter mechanisms and candidate genes providing targets for new drug development that could potentially improve cognitive function in patients. However, one important shortcoming with the commonly used EEG visual response paradigms is that they yield responses that derive from the simultaneous activation of many visual processing regions. As a result, they are difficult to interpret and any inferences drawn on them are difficult to validate in terms of underlying mechanisms. In this talk I will discuss several studies that suggest that the visual processing deficits seen in patients with schizophrenia are likely to be highly specific in terms of their neural substrates. And I will discuss novel approaches for eliciting EEG-based measures of processing from specific visual cortical areas in relative isolation.